How 100 Enterprise CIOs Are Building and Buying Gen AI in 2025

Author: Sarah Wang, Shangda Xu, Justin Kahl, Tugce Erten · Publication: Andreessen Horowitz (a16z)
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Summary: Updated enterprise AI survey showing 81% of enterprises now use 3+ model families, with data on procurement patterns, multi-model optimization, and Anthropic's growing enterprise penetration.

Editorial Notes

The most current enterprise AI survey available, based on interviews with 100 CIOs at Fortune 500 and large enterprises. The headline finding for technical leaders: multi-model is now the default, with 37% using 5+ models and 81% using 3+ model families. This is a fundamental architectural decision, not just vendor diversification — it means your system needs model-agnostic abstractions, routing logic, and per-model cost tracking. The article also reveals that AI procurement is converging with traditional enterprise software patterns (security reviews, compliance requirements, vendor consolidation), which has direct implications for how you structure your provider relationships. Compare this 2025 data with the earlier 2024 survey (also in this knowledge base) to see the acceleration trajectory. The shift from experimentation to production workloads means architecture decisions made now will be load-bearing for years.

Source: AI Strategy & Leadership
Link last verified: 2026-04-08